Plain-English translation of NCT04449068 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is tracking people with severe Tourette syndrome who have had a surgical procedure called deep brain stimulation (DBS) — a device placed in the brain to help control tics. The French research team wants to carefully measure how well this treatment works before and after surgery, and to understand how it affects not just the tics themselves, but also other health concerns, mood, thinking abilities, and quality of life.
Even though earlier research showed that this treatment helps reduce tics over time, doctors still have many unanswered questions about how well the treatment works for different people and what factors predict who will benefit most. By collecting detailed information from every patient treated this way, the research team hopes to better understand this treatment and plan larger international studies in the future.
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If you join this study, you will have detailed evaluations before your surgery and then once a year for five years after surgery. These visits will include neurological exams, thinking and psychological tests, and assessments of how your tics and overall quality of life are doing. The research team will also track how your medications and stimulation settings change over time to build a complete picture of your recovery.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
France
Sponsor
Assistance Publique - Hôpitaux de Paris
Enrollment target
~20 participants
Started
January 2021
Primary completion
June 2036
Age range
15 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Andreas HARTMANN, MD
Assistance Publique - Hôpitaux de Paris
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.