Plain-English translation of NCT04454203 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
During ankle surgery, surgeons use a tourniquet—a device that squeezes your leg to reduce bleeding. This often causes blood pressure to spike unexpectedly. This study is testing whether , a numbing medication injected near your femoral artery (the large artery in your leg), can help keep your blood pressure closer to normal during surgery. You'll receive either the medication or a placebo saline injection to compare how well it works.
Tourniquet-related high blood pressure is a common problem during leg and ankle surgery that can be uncomfortable and potentially risky for some patients. Researchers want to see if this medication can safely and effectively prevent or reduce this dangerous blood pressure spike.
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You will be randomly assigned to receive either the numbing medication or a saline placebo injection near your femoral artery before your scheduled ankle surgery. The injection will be given through a thin catheter (tube), and your blood pressure will be monitored closely during the procedure to see if the medication helps prevent the tourniquet-related blood pressure spike. Your participation lasts about 24 hours, and all other aspects of your anesthesia and surgery care will remain the same.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
United States