Plain-English translation of NCT04461821 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing a new technology called Secondary Electrospray Ionization Mass Spectrometry (SESI-MS) that analyzes your breath to detect chemical markers related to disease and medication. By studying what's in your exhaled breath, doctors hope to understand how well medications are working in your body and how to personalize your dose to work best for you.
Current ways of monitoring medications often require repeated blood tests, which can be uncomfortable and inconvenient for children. This study exists to see if analyzing breath could offer a non-invasive, easier way to monitor how medications are working and help doctors give each patient the right dose for their specific condition.
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You would breathe into a special device that collects and analyzes your exhaled breath — a simple, painless test that takes only a few minutes. This would happen during your regular clinic visits or hospital stays while you're already receiving standard care for your condition. The researchers will collect this breath sample information alongside your normal medical information to see if the breath analysis helps doctors better understand your treatment needs.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
Switzerland
Sponsor
University Children's Hospital Basel
Collaborators
Swiss National Science Foundation, Fondation Botnar (Switzerland)
Enrollment target
~3,600 participants
Started
September 2020
Primary completion
July 2030
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Pablo Sinues, Prof. Dr.
University Children's Hospital Basel
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.