Plain-English translation of NCT04462042 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study compares two different types of radiation therapy for people with anal cancer: traditional photon radiation (which most patients currently receive) and newer proton radiation (which may damage surrounding healthy tissue less). Both types of radiation are delivered in the same dose and schedule, but the trial is testing whether proton therapy causes fewer painful side effects during and after treatment, particularly to the bone marrow and nearby bowel.
Anal cancer treatment is usually successful at controlling the disease, but it causes substantial side effects during and after therapy that can be very uncomfortable for patients. This new treatment may reduce those side effects by more precisely targeting the cancer and sparing healthy tissue from radiation damage.
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You will receive radiation therapy five days a week for 5.5 weeks (27 total sessions). You will be randomly assigned to receive either traditional photon radiation or newer proton radiation—both deliver the same total dose to your cancer in the same schedule. Throughout treatment, you will be monitored for side effects through both medical assessments and by reporting your own experience. The study will track both immediate side effects (during and shortly after treatment) and longer-term effects over time.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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