Plain-English translation of NCT04471129 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two different ways to give oxygen to people with chronic heart failure who have just had heart surgery. The study will compare high-flow oxygen therapy with non-invasive ventilation (a mask that helps you breathe) to see which one is better at supporting your heart and lungs during recovery. Both treatments are already used in hospitals, but this study wants to understand how they affect your heart function.
After heart surgery, patients with weakened hearts are at risk for complications. Doctors want to know which oxygen delivery method—high-flow oxygen or non-invasive ventilation—is safest and most effective for helping the heart recover during this critical time.
You likely qualify if…
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You would receive two different oxygen therapies in a specific order, with a washout period of regular oxygen in between. One group would try high-flow oxygen therapy first, then regular oxygen, then non-invasive ventilation. The other group would do non-invasive ventilation first, then regular oxygen, then high-flow oxygen. Throughout this time, doctors would carefully monitor your heart function, oxygen levels, and vital signs using the catheters already in place from your surgery to understand how each treatment affects your recovery.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
France
Sponsor
University Hospital, Rouen
Enrollment target
~30 participants
Started
September 2020
Primary completion
September 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Elisabeth Surlemont, Dr
University Hospital, Rouen
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.