Plain-English translation of NCT04477785 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →The Parkinson's Progression Markers Initiative (PPMI) is a long-term research study that follows people newly diagnosed with Parkinson's disease and healthy volunteers to understand how the disease changes over time. By collecting detailed information through regular clinical visits, blood tests, brain scans, and other measurements, this study aims to identify early signs of Parkinson's that might help doctors detect and treat the disease sooner.
Parkinson's disease affects each person differently, and doctors don't yet have reliable ways to predict how quickly someone's symptoms will progress or which treatments will work best. This study exists to create a detailed picture of how the disease develops in its early stages, which could eventually lead to better ways to diagnose and slow Parkinson's before major symptoms appear.
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If you join, you'll visit the study clinic multiple times over 5-8 years for detailed assessments of your symptoms and overall health. At these visits, you may have physical examinations, brain imaging scans, blood and spinal fluid tests, and questionnaires about how you're feeling. Some visits may also involve wearing devices to track your movement or using a study app on your phone to share information between clinic visits.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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