Plain-English translation of NCT04486131 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying whether a surgical procedure to remove enlarged lymph nodes in the pelvis can improve outcomes for people with rectal cancer. Researchers have found that some patients with enlarged lymph nodes in the lateral pelvic region have a higher risk of cancer coming back, even after standard treatment. This study is examining whether removing these lymph nodes during surgery can lower that recurrence risk.
Standard treatment for rectal cancer has dramatically reduced cancer recurrence, but patients with enlarged lymph nodes in the lateral pelvic region still have a concerning 20% recurrence rate. Early results suggest that surgically removing these lymph nodes may significantly reduce recurrence in this higher-risk group, but more research is needed to confirm this approach.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will have your imaging scans reviewed by the research team using a standardized protocol to assess your lymph nodes. You will then undergo surgery to remove the enlarged lymph nodes as part of your rectal cancer treatment. The trial will track your outcomes over time to see if this approach reduces the risk of cancer recurrence compared to standard treatment alone.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
Netherlands
Enrollment target
~200 participants
Started
October 2020
Primary completion
October 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Miranda Kusters, MD, PhD
VUMedicalCentre
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.