Plain-English translation of NCT04491929 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying how the body responds to a treatment called Selective Internal Radiation Therapy (SIRT), which uses tiny radioactive beads delivered directly to tumors in the liver. Researchers want to understand the biological changes that happen in your blood before and after this treatment by analyzing blood samples. The goal is to learn more about how this treatment works and whether certain genetic markers in your blood can help predict how well it will work for you.
Colorectal cancer that has spread to the liver can be difficult to treat, especially when surgery or other standard treatments are no longer an option. This study exists to better understand the biological effects of this specialized radiation treatment so doctors can improve how they use it and potentially predict which patients will benefit most.
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If you join this study, you will receive SIRT treatment as it is normally given at Aarhus University Hospital. The main difference is that the medical team will draw blood samples from you before your treatment and during follow-up visits to study biological changes in your blood. These samples will be analyzed for cell-free DNA and specific genetic markers related to your cancer. The study is observational, meaning the researchers are watching and learning from your treatment rather than testing a new medication—the radiation treatment itself is standard care for your condition.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
Denmark
Sponsor
Aarhus University Hospital
Enrollment target
~30 participants
Started
November 2020
Primary completion
February 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Louise B Callesen, MD
Experimental Clinical Oncology
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.