Plain-English translation of NCT04493385 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is collecting information from heart transplant patients who received donor hearts from people with hepatitis C exposure. Researchers want to understand how well these transplants work now that highly effective antiviral medications are available to treat hepatitis C after transplant. By gathering real-world data from transplant centers across the country, the study aims to make sure this expanded donor pool is safe and beneficial for patients who need new hearts.
For many years, hearts from donors with hepatitis C were rarely used because doctors worried about infection risk and poorer outcomes. However, new antiviral medications can now cure hepatitis C quickly and effectively after transplant. Many transplant centers have started using these donor hearts as standard practice, but we need to track how patients actually do to make sure this approach is truly safe and to help other centers make informed decisions.
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This is a registry study, meaning researchers will collect and review your medical information and transplant outcomes over time—you won't need to take any new medication or come in for extra visits. Your transplant center will share your health records and follow-up test results with the study team to help build a nationwide picture of how patients with hepatitis C-positive donor hearts are doing.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
Baylor Research Institute
Enrollment target
~500 participants
Started
September 2019
Primary completion
December 2030
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Joost Felius, PhD
BSWRI
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