Plain-English translation of NCT04510025 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study, called C-MORE, follows people who had moderate to severe COVID-19 to see if the virus causes lasting damage to organs like the lungs, heart, brain, liver, and kidneys. Researchers will use advanced MRI imaging—a safe scanning technology—combined with breathing tests, exercise assessments, and mental health evaluations to understand whether COVID-19 survivors experience ongoing organ injury.
While we know COVID-19 primarily affects the lungs, early evidence shows it may damage multiple organs at once. This study exists because doctors don't yet know how many survivors have lasting organ damage or how this damage affects people's daily lives, and understanding these long-term effects is critical to helping patients recover.
You likely qualify if…
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If you join this study, you will visit the research center three times: at 3 months, 6 months, and 12 months after your COVID-19 symptoms started. During each visit, you'll have an MRI scan of your organs, breathing tests, an exercise capacity test, and assessments of your thinking ability and mental health. The entire study lasts about one year, and researchers are also recruiting healthy volunteers without COVID-19 to compare with participants who had the infection.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United Kingdom
Enrollment target
~750 participants
Started
May 2020
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 100 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Betty Raman, MBBS, DPhil, FRACP
University of Oxford
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.