A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases — Stella
Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.
(331 sites) United States
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama Thomas Hospital, Fairhope, Alabama Mobile Infirmary Medical Center, Mobile, Alabama Anchorage Associates in Radiation Medicine, Anchorage, Alaska Anchorage Radiation Therapy Center, Anchorage, Alaska Alaska Breast Care and Surgery LLC, Anchorage, Alaska Alaska Oncology and Hematology LLC, Anchorage, Alaska Alaska Women's Cancer Care, Anchorage, Alaska Anchorage Oncology Centre, Anchorage, Alaska Katmai Oncology Group, Anchorage, Alaska Providence Alaska Medical Center, Anchorage, Alaska Fairbanks Memorial Hospital, Fairbanks, Alaska Mercy Hospital Fort Smith, Fort Smith, Arkansas Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California Epic Care-Dublin, Dublin, California Bay Area Breast Surgeons Inc, Emeryville, California Epic Care Partners in Cancer Care, Emeryville, California UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California Contra Costa Regional Medical Center, Martinez, California Providence Queen of The Valley, Napa, California Alta Bates Summit Medical Center - Summit Campus, Oakland, California Bay Area Tumor Institute, Oakland, California Sharp Memorial Hospital, San Diego, California Providence Medical Foundation - Santa Rosa, Santa Rosa, California Providence Santa Rosa Memorial Hospital, Santa Rosa, California Epic Care Cyberknife Center, Walnut Creek, California Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado The Medical Center of Aurora, Aurora, Colorado University of Colorado Hospital, Aurora, Colorado Boulder Community Foothills Hospital, Boulder, Colorado Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado Rocky Mountain Cancer Centers - Centennial, Centennial, Colorado The Women's Imaging Center, Denver, Colorado Colorado Blood Cancer Institute, Denver, Colorado Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado Rocky Mountain Cancer Centers-Midtown, Denver, Colorado Rocky Mountain Cancer Centers-Rose, Denver, Colorado Rose Medical Center, Denver, Colorado Western Surgical Care, Denver, Colorado Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado Rocky Mountain Cancer Centers - Swedish, Englewood, Colorado Swedish Medical Center, Englewood, Colorado The Melanoma and Skin Cancer Institute, Englewood, Colorado North Colorado Medical Center, Greeley, Colorado Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado Sky Ridge Medical Center, Lone Tree, Colorado McKee Medical Center, Loveland, Colorado Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida Orlando Health Cancer Institute, Orlando, Florida UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida Moffitt Cancer Center-International Plaza, Tampa, Florida Moffitt Cancer Center - McKinley Campus, Tampa, Florida Moffitt Cancer Center, Tampa, Florida Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho Saint Luke's Cancer Institute - Boise, Boise, Idaho Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho Walter Knox Memorial Hospital, Emmett, Idaho Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho Idaho Urologic Institute-Meridian, Meridian, Idaho Saint Luke's Cancer Institute - Meridian, Meridian, Idaho Saint Luke's Cancer Institute - Nampa, Nampa, Idaho Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho Kootenai Cancer Clinic, Sandpoint, Idaho Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho Saint Anthony's Health, Alton, Illinois Rush - Copley Medical Center, Aurora, Illinois Illinois CancerCare-Bloomington, Bloomington, Illinois Illinois CancerCare-Canton, Canton, Illinois Memorial Hospital of Carbondale, Carbondale, Illinois SIH Cancer Institute, Carterville, Illinois Illinois CancerCare-Carthage, Carthage, Illinois Centralia Oncology Clinic, Centralia, Illinois Saint Mary's Hospital, Centralia, Illinois Northwestern University, Chicago, Illinois Carle at The Riverfront, Danville, Illinois Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois Decatur Memorial Hospital, Decatur, Illinois Illinois CancerCare-Dixon, Dixon, Illinois Carle Physician Group-Effingham, Effingham, Illinois Crossroads Cancer Center, Effingham, Illinois Illinois CancerCare-Eureka, Eureka, Illinois Illinois CancerCare-Galesburg, Galesburg, Illinois Western Illinois Cancer Treatment Center, Galesburg, Illinois Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois Illinois CancerCare-Macomb, Macomb, Illinois Good Samaritan Regional Health Center, Mount Vernon, Illinois Cancer Care Center of O'Fallon, O'Fallon, Illinois Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois Illinois CancerCare-Pekin, Pekin, Illinois Illinois CancerCare-Peoria, Peoria, Illinois Methodist Medical Center of Illinois, Peoria, Illinois Illinois CancerCare-Peru, Peru, Illinois Valley Radiation Oncology, Peru, Illinois Illinois CancerCare-Princeton, Princeton, Illinois Southern Illinois University School of Medicine, Springfield, Illinois Springfield Clinic, Springfield, Illinois Memorial Medical Center, Springfield, Illinois Southwest Illinois Health Services LLP, Swansea, Illinois Carle Cancer Center, Urbana, Illinois The Carle Foundation Hospital, Urbana, Illinois Illinois CancerCare - Washington, Washington, Illinois Rush-Copley Healthcare Center, Yorkville, Illinois Reid Health, Richmond, Indiana Mary Greeley Medical Center, Ames, Iowa McFarland Clinic - Ames, Ames, Iowa McFarland Clinic - Boone, Boone, Iowa Saint Anthony Regional Hospital, Carroll, Iowa Iowa Methodist Medical Center, Des Moines, Iowa Medical Oncology and Hematology Associates-Des Moines, Des Moines, Iowa Broadlawns Medical Center, Des Moines, Iowa Iowa Lutheran Hospital, Des Moines, Iowa McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa Trinity Regional Medical Center, Fort Dodge, Iowa McFarland Clinic - Jefferson, Jefferson, Iowa McFarland Clinic - Marshalltown, Marshalltown, Iowa Methodist West Hospital, West Des Moines, Iowa Central Care Cancer Center - Garden City, Garden City, Kansas Central Care Cancer Center - Great Bend, Great Bend, Kansas Mercy Health - Paducah Medical Oncology and Hematology, Paducah, Kentucky University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan Bronson Battle Creek, Battle Creek, Michigan University of Michigan - Brighton Center for Specialty Care, Brighton, Michigan Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan Spectrum Health at Butterworth Campus, Grand Rapids, Michigan Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan Bronson Methodist Hospital, Kalamazoo, Michigan West Michigan Cancer Center, Kalamazoo, Michigan Ascension Borgess Cancer Center, Kalamazoo, Michigan Borgess Medical Center, Kalamazoo, Michigan Trinity Health Muskegon Hospital, Muskegon, Michigan Lakeland Hospital Niles, Niles, Michigan Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan Spectrum Health Reed City Hospital, Reed City, Michigan Lakeland Medical Center Saint Joseph, Saint Joseph, Michigan Marie Yeager Cancer Center, Saint Joseph, Michigan Munson Medical Center, Traverse City, Michigan University of Michigan Health - West, Wyoming, Michigan Fairview Ridges Hospital, Burnsville, Minnesota Minnesota Oncology - Burnsville, Burnsville, Minnesota Cambridge Medical Center, Cambridge, Minnesota Mercy Hospital, Coon Rapids, Minnesota Fairview Southdale Hospital, Edina, Minnesota Unity Hospital, Fridley, Minnesota Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota Saint John's Hospital - Healtheast, Maplewood, Minnesota Abbott-Northwestern Hospital, Minneapolis, Minnesota Hennepin County Medical Center, Minneapolis, Minnesota Health Partners Inc, Minneapolis, Minnesota Monticello Cancer Center, Monticello, Minnesota New Ulm Medical Center, New Ulm, Minnesota Fairview Northland Medical Center, Princeton, Minnesota North Memorial Medical Health Center, Robbinsdale, Minnesota Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota Regions Hospital, Saint Paul, Minnesota United Hospital, Saint Paul, Minnesota Saint Francis Regional Medical Center, Shakopee, Minnesota Lakeview Hospital, Stillwater, Minnesota Ridgeview Medical Center, Waconia, Minnesota Rice Memorial Hospital, Willmar, Minnesota Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota Fairview Lakes Medical Center, Wyoming, Minnesota Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri Central Care Cancer Center - Bolivar, Bolivar, Missouri Cox Cancer Center Branson, Branson, Missouri Saint Francis Medical Center, Cape Girardeau, Missouri Southeast Cancer Center, Cape Girardeau, Missouri Parkland Health Center - Farmington, Farmington, Missouri Capital Region Southwest Campus, Jefferson City, Missouri Freeman Health System, Joplin, Missouri Mercy Hospital Joplin, Joplin, Missouri Delbert Day Cancer Institute at PCRMC, Rolla, Missouri Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri Heartland Regional Medical Center, Saint Joseph, Missouri Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri Mercy Hospital Springfield, Springfield, Missouri CoxHealth South Hospital, Springfield, Missouri Saint Louis Cancer and Breast Institute-South City, St Louis, Missouri Mercy Hospital South, St Louis, Missouri Missouri Baptist Medical Center, St Louis, Missouri Mercy Hospital Saint Louis, St Louis, Missouri Missouri Baptist Sullivan Hospital, Sullivan, Missouri Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills, Missouri Mercy Hospital Washington, Washington, Missouri Community Hospital of Anaconda, Anaconda, Montana Billings Clinic Cancer Center, Billings, Montana Bozeman Deaconess Hospital, Bozeman, Montana Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana Great Falls Clinic, Great Falls, Montana Kalispell Regional Medical Center, Kalispell, Montana Saint Patrick Hospital - Community Hospital, Missoula, Montana Community Medical Hospital, Missoula, Montana Cancer Partners of Nebraska - Pine Lake, Lincoln, Nebraska Southeast Nebraska Cancer Center - 68th Street Place, Lincoln, Nebraska Roswell Park Cancer Institute, Buffalo, New York Wake Forest University at Clemmons, Clemmons, North Carolina Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina Wake Forest Baptist Health - Hematology Oncology - Statesville, Statesville, North Carolina Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro, North Carolina Wake Forest University Health Sciences, Winston-Salem, North Carolina UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio Indu and Raj Soin Medical Center, Beavercreek, Ohio Strecker Cancer Center-Belpre, Belpre, Ohio Saint Elizabeth Boardman Hospital, Boardman, Ohio Dayton Physicians LLC-Miami Valley South, Centerville, Ohio Miami Valley Hospital South, Centerville, Ohio Geauga Hospital, Chardon, Ohio Adena Regional Medical Center, Chillicothe, Ohio University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio Case Western Reserve University, Cleveland, Ohio Ohio State University Comprehensive Cancer Center, Columbus, Ohio Mount Carmel East Hospital, Columbus, Ohio Columbus Oncology and Hematology Associates Inc, Columbus, Ohio Riverside Methodist Hospital, Columbus, Ohio Grant Medical Center, Columbus, Ohio The Mark H Zangmeister Center, Columbus, Ohio Mount Carmel Health Center West, Columbus, Ohio Doctors Hospital, Columbus, Ohio Miami Valley Hospital, Dayton, Ohio Dayton Physician LLC-Miami Valley Hospital North, Dayton, Ohio Miami Valley Hospital North, Dayton, Ohio Delaware Health Center-Grady Cancer Center, Delaware, Ohio Grady Memorial Hospital, Delaware, Ohio Columbus Oncology and Hematology Associates, Dublin, Ohio Dublin Methodist Hospital, Dublin, Ohio Armes Family Cancer Center, Findlay, Ohio Blanchard Valley Hospital, Findlay, Ohio Orion Cancer Care, Findlay, Ohio Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio Dayton Physicians LLC-Atrium, Franklin, Ohio Central Ohio Breast and Endocrine Surgery, Gahanna, Ohio Dayton Physicians LLC-Wayne, Greenville, Ohio Wayne Hospital, Greenville, Ohio Mount Carmel Grove City Hospital, Grove City, Ohio Zangmeister Center Grove City, Grove City, Ohio Greater Dayton Cancer Center, Kettering, Ohio Kettering Medical Center, Kettering, Ohio Fairfield Medical Center, Lancaster, Ohio Saint Rita's Medical Center, Lima, Ohio OhioHealth Mansfield Hospital, Mansfield, Ohio Marietta Memorial Hospital, Marietta, Ohio OhioHealth Marion General Hospital, Marion, Ohio UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio Knox Community Hospital, Mount Vernon, Ohio Mount Carmel New Albany Surgical Hospital, New Albany, Ohio Licking Memorial Hospital, Newark, Ohio Newark Radiation Oncology, Newark, Ohio University Hospitals Parma Medical Center, Parma, Ohio Mercy Health Perrysburg Cancer Center, Perrysburg, Ohio Southern Ohio Medical Center, Portsmouth, Ohio University Hospitals Portage Medical Center, Ravenna, Ohio UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio Springfield Regional Cancer Center, Springfield, Ohio Springfield Regional Medical Center, Springfield, Ohio Saint Vincent Mercy Medical Center, Toledo, Ohio Mercy Health - Saint Anne Hospital, Toledo, Ohio Dayton Physicians LLC - Troy, Troy, Ohio Upper Valley Medical Center, Troy, Ohio University Hospitals Sharon Health Center, Wadsworth, Ohio Saint Joseph Warren Hospital, Warren, Ohio University of Cincinnati Cancer Center-West Chester, West Chester, Ohio Saint Ann's Hospital, Westerville, Ohio UH Seidman Cancer Center at Saint John Medical Center, Westlake, Ohio Saint Elizabeth Youngstown Hospital, Youngstown, Ohio Genesis Healthcare System Cancer Care Center, Zanesville, Ohio University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma Saint Alphonsus Medical Center-Baker City, Baker City, Oregon Saint Charles Health System, Bend, Oregon Clackamas Radiation Oncology Center, Clackamas, Oregon Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon Bay Area Hospital, Coos Bay, Oregon Providence Newberg Medical Center, Newberg, Oregon Saint Alphonsus Medical Center-Ontario, Ontario, Oregon Providence Willamette Falls Medical Center, Oregon City, Oregon Providence Portland Medical Center, Portland, Oregon Providence Saint Vincent Medical Center, Portland, Oregon Saint Charles Health System-Redmond, Redmond, Oregon University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania Avera Cancer Institute, Sioux Falls, South Dakota Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah Providence Regional Cancer System-Aberdeen, Aberdeen, Washington PeaceHealth Saint Joseph Medical Center, Bellingham, Washington Providence Regional Cancer System-Centralia, Centralia, Washington Swedish Cancer Institute-Edmonds, Edmonds, Washington Providence Regional Cancer Partnership, Everett, Washington Swedish Cancer Institute-Issaquah, Issaquah, Washington Kadlec Clinic Hematology and Oncology, Kennewick, Washington Providence Regional Cancer System-Lacey, Lacey, Washington PeaceHealth Saint John Medical Center, Longview, Washington Jefferson Healthcare, Port Townsend, Washington Pacific Gynecology Specialists, Seattle, Washington Swedish Medical Center-Ballard Campus, Seattle, Washington Swedish Medical Center-Cherry Hill, Seattle, Washington Swedish Medical Center-First Hill, Seattle, Washington PeaceHealth United General Medical Center, Sedro-Woolley, Washington Providence Regional Cancer System-Shelton, Shelton, Washington PeaceHealth Southwest Medical Center, Vancouver, Washington Providence Saint Mary Regional Cancer Center, Walla Walla, Washington Providence Regional Cancer System-Yelm, Yelm, Washington Langlade Hospital and Cancer Center, Antigo, Wisconsin Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin Gundersen Lutheran Medical Center, La Crosse, Wisconsin University of Wisconsin Carbone Cancer Center, Madison, Wisconsin Marshfield Medical Center-Marshfield, Marshfield, Wisconsin Aspirus Medford Hospital, Medford, Wisconsin Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin Cancer Center of Western Wisconsin, New Richmond, Wisconsin Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin Ascension Saint Michael's Hospital, Stevens Point, Wisconsin Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin Aspirus Regional Cancer Center, Wausau, Wisconsin Marshfield Medical Center - Weston, Weston, Wisconsin Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin Cheyenne Regional Medical Center-West, Cheyenne, Wyoming Billings Clinic-Cody, Cody, Wyoming Welch Cancer Center, Sheridan, Wyoming Key details Sponsor
SWOG Cancer Research Network
Collaborators
National Cancer Institute (NCI)
Enrollment target
~112 participants
Primary completion
June 2027
Last updated September 2025