Plain-English translation of NCT04517383 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
When you have a severe stroke caused by a blood clot in a major brain artery, doctors perform emergency surgery to remove the clot. This trial is testing whether keeping you gently sedated and on a breathing machine for 6 hours after surgery — instead of waking you up immediately — helps protect your brain and improve your long-term recovery. Researchers believe that the extra resting time might reduce brain damage during the critical hours after the clot is removed.
After stroke surgery, the brain is very vulnerable during the recovery period. Early studies suggest that sedation may protect brain tissue, but the protection was only modest because patients were only sedated during the short surgery itself. This trial tests whether extending this protection for 6 hours after surgery — when the brain is still at high risk — could lead to better healing and less disability.
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If you qualify and enroll, you will receive emergency clot-removal surgery under general anesthesia. Half of participants will be randomly assigned to wake up and come off the breathing machine immediately after surgery (standard care), while the other half will stay sedated and on the breathing machine for 6 additional hours. Both groups will have their blood pressure carefully managed. After the sedation period ends, the extended-sedation group will be woken up and extubated. You will then be monitored in the hospital and followed up to measure how well you recover over the following weeks and months.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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