Testing heat treatment for small pancreatic neuroendocrine tumors

Plain-English translation of NCT04520932 on ClinicalTrials.gov ↗ · Source last updated May 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing radiofrequency ablation — a technique that uses heat delivered through a special endoscope to treat small pancreatic neuroendocrine tumors. The treatment is being studied in people whose tumors are less than 2 centimeters in size and appear to be slow-growing (low-grade). Researchers want to see if this treatment can effectively shrink or eliminate these tumors while keeping patients safe and maintaining their quality of life.

Small, low-grade pancreatic neuroendocrine tumors don't always need major surgery, but they do need treatment. This trial exists to find out whether radiofrequency ablation — a less invasive approach than surgery — can be an effective option for patients with these small tumors.

Do you qualify?

You likely qualify if…

you have a pancreatic neuroendocrine tumor confirmed by biopsy that is less than 2 centimeters in size
your tumor is low-grade (showing slow growth patterns on testing)
your tumor does not produce excess hormones
you are between 18 and 80 years old
you are in generally good health with no serious illnesses that would prevent safe treatment
you do not have signs that the tumor has spread to other parts of your body

You likely don't qualify if…

you are pregnant, breastfeeding, or planning to become pregnant without effective birth control
you have a severe bleeding disorder or take medications that significantly thin your blood
your tumor is located very close to the pancreatic or bile ducts
you have cancer elsewhere in your body that is being actively treated or is getting worse
your overall life expectancy is less than one year

What participation looks like

If you join this trial, you will receive one to three radiofrequency ablation treatment sessions, spaced according to how well your tumor responds. After treatment, you will have regular follow-up visits over 5 years, including imaging scans and blood tests to monitor your tumor and check for any side effects. You'll also be asked about your overall health, quality of life, and any symptoms you experience during this time.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Trial locations(1 site)

France

Institut Paoli Calmettes, Marseille