Heart imaging scans to track amyloid disease and treatment response

This trial is testing whether a new imaging technique can better measure amyloid buildup in patients' hearts and track how well tafamidis (a medication that slows amyloid disease) is working. Doctors currently rely on visual inspection of heart scans to diagnose this rare condition, but researchers believe a more precise, computerized measurement method could help them better understand who is responding to treatment and who might need additional care.

Cardiac transthyretin amyloidosis is a serious heart condition where abnormal proteins build up in the heart muscle, causing heart failure. While this medication has recently been shown to reduce deaths and hospitalizations, doctors need better tools to measure whether the treatment is actually working in individual patients and to predict who will benefit most from therapy.