Plain-English translation of NCT04536103 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are developing faster versions of two special MRI scanning techniques—called T1ρ and T2 imaging—that can detect early cartilage damage in the knee. Right now, these scans take a long time, which can be uncomfortable and expensive. This study will test whether the new faster versions work just as well and produce consistent results across different hospitals and different MRI machines.
Currently, these advanced MRI techniques take too long to use in regular clinical practice, making them uncomfortable for patients and difficult to afford. Additionally, no one has properly tested whether these scans give the same results when done at different hospitals with different equipment—something essential before they can be used in large research studies.
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Depending on which group you join, you will have MRI scans of your knee at one or more hospitals. Some participants will visit Cleveland Clinic only, while others (called 'traveling volunteers') will be scanned at four different medical centers to test whether the scans work the same everywhere. People with ACL tears will have scans at baseline and again at one year. All scans use the new faster imaging techniques being tested in this study.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
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