Plain-English translation of NCT04540692 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether the order of chemotherapy drugs matters for treating advanced breast cancer. You would receive two types of chemotherapy—one starting with doxorubicin and cyclophosphamide, and another starting with —but the study is comparing which sequence works better. The rest of your cancer treatment (surgery, radiation, and hormone therapy) would follow your hospital's standard care plan.
Doctors have always used these chemotherapy drugs together to treat advanced breast cancer, but no one has proven which order gives the best results. This trial will help determine the most effective sequence, so future patients get the best possible outcomes.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two groups that receive the same chemotherapy drugs but in different orders. One group starts with doxorubicin and cyclophosphamide for 3 cycles (about 9 weeks), then moves to for 4 cycles (about 12 weeks). The other group reverses this sequence. You will receive chemotherapy infusions at your hospital every 3 weeks or weekly, depending on which drug is being given. After chemotherapy is complete, you'll have surgery and possibly radiation and hormone therapy as part of standard care.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
Brazil