Plain-English translation of NCT04550494 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called in people with advanced cancer who have specific genetic mutations affecting their DNA repair systems. The study will measure how well the medication works and how it affects tumor cells. Researchers want to understand whether this treatment can help patients whose cancers haven't responded to other therapies.
Some cancers are caused by genetic changes that make cells unable to repair DNA damage properly. This medication is designed to take advantage of that weakness, but researchers need to understand exactly how it works in different patients and which genetic changes predict who will benefit most.
You likely qualify if…
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You would take the medication by mouth once daily for 28-day cycles, repeating as long as the treatment is working and you tolerate it well. Throughout the study, you'll have regular blood tests, imaging scans (CT or MRI), and a tumor biopsy to check how the medication is affecting your cancer cells. The study team will monitor you closely for side effects and tumor response, with a follow-up visit 30 days after you finish treatment.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
United States