Plain-English translation of NCT04551560 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how emotional stress and negative feelings affect the pressure in your lungs when you have heart failure. You'll participate in a one-time lab session where you experience a mild stress task while researchers monitor your lung pressure, plus six months of daily home monitoring using a device you may already have (CardioMEMS). This helps doctors learn why some people with heart failure get sicker during stressful times and others don't.
Heart failure symptoms often get worse when people feel stressed or anxious, but doctors don't fully understand why. This study could help identify which patients are most vulnerable to stress-related worsening, so doctors can offer better support and treatment.
You likely qualify if…
You likely don't qualify if…
You'll visit Yale University Hospital or an outpatient clinic for a single four-hour lab session. There, you'll rest quietly, do a relaxation exercise, complete a mild stress task (like a timed math challenge), and then recover while researchers measure your lung pressure and take a few small blood samples. For the next six months, you'll check your heart pressure each morning using your home monitor (standard care), and spend a few minutes answering quick questions on a tablet or paper about your sleep, stress level, and mood. You'll also fill out questionnaires about your emotions and life stressors online or on paper, whichever you prefer.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Sponsor
Yale University
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~112 participants
Started
December 2020
Primary completion
April 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Rachel Lampert, MD
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.