Plain-English translation of NCT04573140 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new type of treatment called an RNA-lipid particle vaccine designed specifically for each patient's brain tumor. Doctors remove tumor tissue during surgery, use it to create a customized vaccine tailored to your cancer cells, and then give you a series of vaccine injections over several months to help your immune system recognize and fight the cancer. This medication works differently from traditional chemotherapy — it teaches your body's own defenses to attack the tumor.
Current treatments for newly diagnosed glioblastoma and other high-grade brain tumors do not work well enough for many patients. This trial exists to see whether a personalized vaccine approach can help patients live longer and healthier by boosting the immune system's ability to target cancer cells specific to each person's tumor.
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After you have surgery and standard radiation treatment, you will receive 15 vaccine injections over about 14 months — three injections given every 2 weeks, followed by 12 monthly injections. You will have MRI brain scans and clinical check-ups every 3 months during the first year after starting the vaccine, then every 6 to 12 months for the next 2 years to monitor how well the treatment is working. The study team will follow your health and outcomes for as long as needed to understand if this personalized vaccine helps you.
AI-generated summary from trial data · Jun 29, 2026 · Not medical advice
United States