Plain-English translation of NCT04575337 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →This is a large research study looking for early warning signs of Alzheimer's disease by collecting blood samples, spinal fluid samples, brain imaging scans, and memory tests from thousands of people. Researchers hope to identify biological markers — measurable signs in your body and brain — that could help doctors diagnose Alzheimer's much earlier, before significant memory loss occurs. The study will follow participants for 5 years, collecting information repeatedly to validate these new diagnostic tools.
Alzheimer's disease damages the brain long before people notice memory problems. By the time symptoms appear, significant brain damage has already occurred. This study exists to find earlier warning signs through blood tests and brain imaging so that doctors can identify the disease sooner, when treatments may be more helpful.
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You would visit the research center for baseline testing where doctors would perform memory and thinking tests, take blood and possibly spinal fluid samples, perform brain imaging scans, and ask questions about your health history and daily life. Then, you would return once per year for the next 5 years to repeat these tests and provide additional samples so researchers can track changes over time. The study involves no experimental medication — it is purely observational, designed to collect information that will help develop better diagnostic tools for the future.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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