Plain-English translation of NCT04576182 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two different types of talk therapy for people with major depression: supportive-expressive therapy and emotion-focused therapy. Both are evidence-based approaches, but they work in different ways—one focuses on building insight and understanding, while the other focuses on processing emotions. The study aims to figure out which approach works best for different people, based on their individual strengths and weaknesses.
Depression affects many people, but not everyone responds the same way to treatment. This study exists to help doctors understand which therapy approach is most likely to help each person, so treatment can be personalized and more people can get real relief from their symptoms.
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You would attend 16 weekly therapy sessions with a trained therapist, receiving either supportive-expressive or emotion-focused therapy. Throughout the study, you'd complete brief questionnaires on your phone and in person to track your progress, and you may participate in some additional assessments like interviews or simple cognitive tasks. The entire treatment period lasts about 16 weeks, and researchers use multiple ways to measure how you're doing—not just your own reports, but also clinical observations and other objective measures.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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