Plain-English translation of NCT04586959 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a uterine manipulator — a device surgeons use to move and position the uterus during minimally invasive (keyhole) surgery for early-stage endometrial cancer — might accidentally spill cancer cells into the abdomen. Researchers will compare two groups of patients: those who have surgery with the manipulator and those who have surgery without it. They'll check fluid samples taken during surgery to see if cancer cells are present in each group.
Most surgeons use a uterine manipulator during keyhole surgery for uterine cancer because it helps them complete the procedure safely and effectively. However, some doctors worry that moving the uterus this way could push cancer cells out through the fallopian tubes into the abdomen, potentially increasing the risk that cancer could spread or return. This study aims to answer that question directly with real data, so doctors can make the safest choices for their patients.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two groups by computer. Either you will have keyhole surgery with the uterine manipulator device, or keyhole surgery without it. The surgery itself will proceed as it normally would to remove your uterus, cervix, fallopian tubes, and ovaries. During surgery, your doctor will collect a small sample of fluid from your abdomen, which researchers will test for cancer cells. You will then continue with regular follow-up care and appointments as your medical team recommends.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States