Plain-English translation of NCT04591639 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how a medication called dapagliflozin affects calcium handling in the heart muscle of people with heart failure. Some participants have heart failure alone, while others have both heart failure and type 2 diabetes. The study uses special MRI scans to measure calcium in the heart before and after taking the medication or a placebo for 6 months.
Heart failure makes it harder for the heart to pump blood effectively, and problems with how calcium moves in heart cells may play a role. Researchers believe this medication might help improve calcium handling and overall heart function, but they need to test whether this actually happens in patients.
You likely qualify if…
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You will have an initial visit for blood tests, heart ultrasound, and a detailed heart scan (MRI). If you qualify for the main treatment part, you'll be randomly assigned to take either the medication or a placebo pill once daily for 6 months. You'll return for follow-up scans at 1 month and 6 months, with blood pressure and heart rhythm monitoring during the longer scans. The special MRI scans take about 45–60 minutes each.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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