Radiation therapy added to immunotherapy for melanoma with involved lymph nodes

This trial is testing whether adding radiation therapy to immunotherapy can help prevent melanoma from coming back in the lymph nodes. You have melanoma that has spread to a sentinel lymph node (the first lymph node where cancer often spreads), and your doctor has recommended immunotherapy as part of your treatment. The study will randomly assign you to receive either immunotherapy alone or immunotherapy plus radiation therapy, and follow you for up to 5 years to see which approach works better.

After surgery for melanoma with lymph node involvement, cancer sometimes comes back in nearby lymph nodes even with immunotherapy. Researchers want to know if adding radiation therapy to immunotherapy can reduce the chance of the cancer returning in these areas.