Plain-English translation of NCT04603404 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing whether advanced heart imaging—including special MRI scans, ultrasound, and nuclear imaging—can help doctors better diagnose and understand a condition called heart failure with preserved ejection fraction (HFpEF). HFpEF is a puzzling form of heart failure where the heart's main pumping chamber appears to work normally on standard tests, yet patients still experience heart failure symptoms. The study hopes that these newer imaging techniques can catch early changes in the heart that standard tests miss.
HFpEF affects more than half of all heart failure patients, but it's hard to diagnose because routine tests often look normal. Currently, there are no proven, highly effective treatments. By using advanced imaging to spot hidden heart problems earlier, doctors hope to identify and help patients sooner, improving their quality of life and survival.
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As a participant, you would undergo several non-invasive heart imaging tests, likely including cardiac MRI (a detailed magnetic imaging scan), echocardiography (ultrasound of the heart), and possibly nuclear imaging. These tests are painless and help doctors visualize your heart's structure, function, and tissue in ways standard tests cannot. The exact number of visits and timeline are not fully specified in this trial description, but you should expect visits to a heart imaging center where trained technicians perform these scans.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
China
Sponsor
Chinese Academy of Medical Sciences, Fuwai Hospital
Enrollment target
~430 participants
Started
January 2019
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Last updated on clinicaltrials.gov in November 2022.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Minjie Lu, PhD
Fuwai Hospital, National Center for Cardiovascular Diseases.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.