Comparing radiation therapy approaches for early-stage prostate cancer with limited spread

Plain-English translation of NCT04610372 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing four different ways to deliver radiation therapy to treat prostate cancer that has spread to a limited number of bones or lymph nodes. You would receive one of these treatments: standard radiation over 4 weeks, a single high-dose radiation procedure, permanent radioactive seed implants, or a focused stereotactic radiation technique. The goal is to find out which approach works best while causing the least amount of urinary side effects.

Men with this type of early-stage spread prostate cancer need treatment, but doctors aren't sure which radiation method is safest and most effective. This trial will help determine the best approach by comparing how these different treatments affect quality of life and cancer outcomes.

Do you qualify?

You likely qualify if…

you have been newly diagnosed with prostate cancer that has spread to fewer than 5 bones and/or non-regional lymph nodes
you have a pathology-confirmed prostate cancer diagnosis
you are willing and able to complete quality-of-life questionnaires and study assessments over 2 years
you plan to receive long-term hormone therapy (at least 9 months) as part of your treatment
you are in good enough health to tolerate the cancer treatment (performance status 0–2)

You likely don't qualify if…

you have high metastatic burden (5 or more bone metastases or cancer spread to organs)
you have had previous pelvic radiation therapy
you have active inflammatory bowel disease
you have had a prior transurethral resection of the prostate (for brachytherapy arms)
you have received prior prostate cancer treatment other than hormone therapy

What participation looks like

After enrollment, you will be randomly assigned to one of four radiation treatment groups. You'll receive either 20 outpatient radiation sessions over 4 weeks, a single outpatient high-dose procedure, a permanent seed implant procedure, or 5 focused radiation sessions over 1–2 weeks. Throughout your first 2 years, you'll have study visits at 6 different timepoints where you'll complete questionnaires about urinary symptoms, bowel function, sexual function, and overall quality of life, and you'll be monitored for cancer progression and survival.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Comparing radiation therapy approaches for early-stage prostate cancer with limited spread

What is this trial?

Do you qualify?

What participation looks like

Trial locations(4 sites)