Plain-English translation of NCT04613921 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research study that tracks 3,000 patients with advanced liver cirrhosis—particularly those experiencing acute-on-chronic liver failure (ACLF), a sudden worsening of chronic liver disease. Researchers will compare survival rates and quality of life for patients who receive liver transplants versus those who don't, to help doctors better understand who should be prioritized for transplantation and improve how donated organs are allocated.
Currently, doctors don't have clear guidelines about which patients with severe liver failure benefit most from transplantation, and there's no good system for predicting which patients on the waiting list are most likely to die while waiting. This study aims to create better tools to predict outcomes and make fairer decisions about organ allocation.
You likely qualify if…
You likely don't qualify if…
This is an observational study, meaning you won't receive a new medication or procedure—instead, researchers will collect information about your liver disease, your medical care, and your outcomes over time. You will be assigned to one of three groups based on your transplant status (listed with severe failure, listed without severe failure, or evaluated but not listed), and the study team will track your health, survival, and quality of life for at least one year, comparing outcomes across groups.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States