Transplanting a donor bladder alongside a kidney transplant

This is an early-phase surgical trial testing concomitant renal and urinary bladder allograft transplantation—meaning doctors will transplant both a donor kidney and a donor bladder into the same person. The study is for people whose kidneys are failing because of severe bladder dysfunction or complete bladder absence, and whose bladder problems haven't improved with medication or other treatments. Instead of reconstructing a bladder from intestines (the current standard), this trial explores whether using a donated bladder works better.

Many people with kidney failure also have bladders that don't work properly or are missing entirely. Currently, doctors must perform two separate procedures: reconstruct or replace the bladder using intestines, and then later transplant a new kidney. This trial exists to see whether transplanting a real donor bladder at the same time as the kidney transplant could be safer, more effective, and require fewer surgeries overall.