Plain-English translation of NCT04628078 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study is tracking the real-world outcomes of a procedure called left atrial appendage closure (LAAC), which is used to treat patients with atrial fibrillation—a condition where the heart beats irregularly. The procedure uses ultrasound guidance to place a small device inside the heart to reduce stroke risk in patients who cannot safely take blood-thinning medications. Researchers want to understand how well this treatment works and what factors affect its success.
Many patients with irregular heartbeat cannot take standard blood-thinning medications due to other health conditions or side effects. This study exists to gather real-world data on how the closure procedure performs in everyday clinical practice, so doctors can better understand who benefits most and how to improve the procedure over time.
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After you receive the closure procedure, you will be monitored as part of this registry for up to 5 years. You will have follow-up visits and imaging tests (such as ultrasound or CT scans) at specific time points—1 to 3 months after the procedure, and then at 1, 3, and 5 years. The study team will track information about your procedure, any complications, medications you take afterward, and your overall health outcomes during these follow-up visits.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
Switzerland
Sponsor
Insel Gruppe AG, University Hospital Bern
Enrollment target
~1,000 participants
Started
August 2015
Primary completion
June 2023
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Lorenz Räber, Prof.
Insel Gruppe AG, Inselspital, Universitätsklinik für Kardiologie
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.