Plain-English translation of NCT04633356 on ClinicalTrials.gov ↗ ·
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new procedure called EUS-guided portal pressure gradient measurement (PPGM) to measure pressure buildup in the liver. Currently, doctors use a difficult procedure that requires threading a catheter through a vein in your neck—but the new method uses ultrasound passed through your stomach instead, which is simpler and safer. Early testing shows this new approach works just as well as the old method and causes no harm to patients.
Right now, the only reliable way to measure dangerous pressure buildup in the liver requires an invasive procedure that is hard to perform and many patients find uncomfortable. This trial exists to prove that a simpler ultrasound-based method can measure the same thing safely and effectively, giving doctors an easier way to monitor liver disease and predict which patients are at risk of serious complications.
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You would come to the hospital for an endoscopy procedure where doctors pass a special ultrasound probe down your throat to measure the pressure in your liver blood vessels. The procedure is done while you are sedated so you won't feel discomfort. This is a one-time measurement that replaces the older, more invasive way of measuring the same thing, and takes about 30 minutes to an hour.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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