Plain-English translation of NCT04637620 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether a medication called , which works differently than most current antidepressants, can help treat depression. Researchers want to see if the medication reduces depression symptoms and improves memory and thinking skills compared to a common antidepressant called and a placebo. The study will last 8 weeks, and you'll be randomly placed into one of the three groups.
Many people with depression don't get enough relief from current antidepressants, or they experience bothersome side effects that make them stop taking medication. This medication targets a different part of the brain than standard treatments, and early research suggests it may also help improve memory and thinking problems that often come with depression.
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You will visit the clinic every 2 weeks for 8 weeks while taking your assigned treatment (the new medication, , or placebo). At each visit, the research team will check how you're doing, ask about any side effects, and measure your depression symptoms. At the start and end of the study, you'll also complete thinking and memory tests to see if the treatment helps improve those areas as well.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
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