Plain-English translation of NCT04643327 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a proof-of-concept study testing whether , a medication originally developed to treat seizures, might also help improve memory problems in people with Parkinson's disease. Researchers will use brain imaging to see how the medication affects specific areas of the brain involved in memory. This study aims to understand whether this medication could be a new treatment option for memory difficulties that sometimes occur in Parkinson's disease.
Memory problems are common in people with Parkinson's disease and can lead to dementia, but current treatments are limited. Researchers believe this medication might help protect the brain areas responsible for memory, and this trial will test whether that approach works.
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You will take either the test medication or a placebo (a look-alike pill with no active ingredient) twice daily for 14 days, then after a break, switch to the other treatment for another 14 days — this crossover design helps researchers see the real effect of the medication. During the study, you'll have brain imaging scans and memory tests to measure any changes. The researchers will compare how your brain activity and memory performance differ between when you're taking the medication and when you're taking placebo.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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