Plain-English translation of NCT04644016 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing cord blood transplantation — a procedure where stem cells from donated umbilical cord blood are infused into children and young adults with life-threatening blood cancers or blood disorders. Before the transplant, participants receive special chemotherapy medicines (, , and ) to prepare their body. The goal is to see if this approach can cure these serious conditions in patients who don't have a matched family donor available.
Many children with blood cancers or serious blood disorders need a stem cell transplant to survive, but finding a matched donor can be difficult and time-consuming. This trial investigates whether cord blood — which is easier to obtain and less likely to cause complications — can be an effective alternative treatment.
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You would be admitted to the hospital for several weeks. First, you'll receive chemotherapy medicines over several days to prepare your body for the transplant. On day zero, doctors will infuse the cord blood stem cells into your bloodstream — a procedure similar to a blood transfusion. After transplant, you'll receive supportive care and medications to prevent rejection and complications, with close monitoring through blood tests and imaging scans. Follow-up visits will continue for at least one year to track your recovery and health.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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