Plain-English translation of NCT04652609 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Chemotherapy can damage nerves in your hands and feet, causing pain and numbness that lasts long after treatment ends. This trial is testing whether a supervised exercise program combined with blood flow restriction (using special cuffs on your limbs) can strengthen and protect your nerves during taxane-based chemotherapy, preventing this side effect before it starts.
Currently, there is no cure once nerve damage from chemotherapy develops. Researchers believe that preparing your body through exercise before and during treatment might protect your nerves from harm, similar to how training prepares muscles for stress.
You likely qualify if…
You likely don't qualify if…
You would attend 24 to 36 one-hour exercise sessions scheduled around your chemotherapy appointments. Each session includes aerobic exercise (like walking or cycling), strength training, and gentle fascial release work (soft tissue stretching). A special blood flow restriction cuff is worn on your arms or legs during exercise to enhance the protective effect. Your exercise schedule adjusts based on how you're feeling and recovering from chemotherapy.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Spain
Universidad de Granada
Enrollment target
~25 participants
Started
January 2021
Primary completion
January 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 70 Years
Sex
Female only
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Irene Cantarero-Villanueva, PhD
Physical Therapy Deparment, Faculty of Health Sciences, University of Granada
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.