Plain-English translation of NCT04664686 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing two different approaches to treating patients who have both heart failure and atrial fibrillation (an irregular heartbeat) and already have a special pacemaker called a CRT device. One approach tries to restore a normal heart rhythm, while the other approach focuses on slowing down the irregular heartbeat. Researchers want to understand which approach works better for people in your situation.
Many people with heart failure also develop an irregular heartbeat, which can prevent their pacemaker from working properly. Doctors are not sure whether it's better to try to fix the rhythm problem or simply control the heart rate, so this study will help answer that important question.
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If you join this trial, you will first complete baseline tests including heart ultrasounds, heart imaging scans, exercise tests, and blood work. Then you will be randomly assigned to receive one of two procedures: either a procedure to restore your heart's normal rhythm or a procedure to slow down your irregular heartbeat. During the procedure, doctors will also measure how well your heart is pumping using special pressure wires. After your procedure, you will have follow-up visits to monitor how you are doing.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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