Plain-English translation of NCT04667494 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing a heart procedure called sonotherapy — which uses ultrasound waves combined with special imaging contrast — to treat cardiac amyloidosis, a disease where abnormal proteins damage the heart muscle. Researchers will enroll 70 people: some with light chain amyloidosis, some with transthyretin amyloidosis, and some without amyloidosis (as a comparison group). Everyone will receive the ultrasound treatment and undergo heart imaging tests before and after to see if the treatment helps.
Cardiac amyloidosis is a serious condition that weakens the heart, and current treatment options are limited. This trial is testing whether sonotherapy — a newer ultrasound-based approach — might improve how the heart works in people with this disease.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will come in for a visit where you'll have a resting heart ultrasound (echocardiogram), a special PET scan to check how blood flows through your heart, and then receive the sonotherapy treatment with imaging contrast and high-intensity ultrasound waves. The entire visit will take a few hours, and you'll need to be able to lie still during the imaging. The study team will monitor your heart and overall health throughout.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Brigham and Women's Hospital
Enrollment target
~70 participants
Started
August 2023
Primary completion
April 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sharmila Dorbala, MD
Brigham and Women's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.