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Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether an adapted physical activity program—combining supervised gym sessions with at-home exercises—can help improve outcomes in older adults being treated with RCHOP chemotherapy for diffuse large B cell lymphoma. The research focuses on whether exercise can prevent muscle loss and weakness (a common side effect called sarcopenia) that occurs during cancer treatment and reduce the chance of relapse.
Many older patients lose significant muscle mass and strength during chemotherapy, which is linked to worse survival outcomes and more complications. This trial exists to see whether adding structured exercise and home workouts to standard treatment can prevent this muscle loss and improve long-term survival.
You likely qualify if…
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You would attend supervised exercise sessions at a clinic 3 times per week during your chemotherapy treatment—including strength training, stretching, balance work, and aerobic activities like Nordic walking or cycling. During the first three rounds of chemotherapy, sessions are more intensive and closely supervised; during the remaining cycles, you'll do more exercises on your own at home while continuing some supervised sessions. You'll keep a simple log of your home exercises and how you feel during activity.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
France