Plain-English translation of NCT04677816 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether vitamin D3 supplementation can improve how well chemotherapy works for people with triple negative breast cancer who have low vitamin D levels. Participants will either receive weekly high-dose vitamin D3 alongside their standard chemotherapy, or standard chemotherapy alone (if their vitamin D levels are already normal). The researchers want to see if this medication helps more patients achieve a complete response to treatment.
Triple negative breast cancer is harder to treat than other types of breast cancer, and not all patients respond well to chemotherapy alone. Early research suggests that vitamin D may play a role in how the body fights cancer, so this trial is testing whether adding this treatment could improve outcomes for patients with low vitamin D levels.
You likely qualify if…
You likely don't qualify if…
If you qualify and have low vitamin D levels, you'll take a weekly vitamin D3 supplement (50,000 international units) by mouth starting when your chemotherapy begins and continuing through your treatment. You'll attend regular chemotherapy appointments and doctor visits as part of your normal cancer care. The study team will also collect small tissue samples before and after treatment and stool samples to study how the medication affects your body. You'll be followed for at least 30 days after your last dose to monitor for any side effects.
AI-generated summary from trial data · Sep 15, 2026 · Not medical advice
United States