Plain-English translation of NCT04677998 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing a new personalized surveillance and treatment plan for people with familial adenomatous polyposis (FAP), a genetic condition that causes many polyps to grow in the digestive system. The study aims to find the best way to monitor and remove polyps from the stomach and duodenum—a part of the small intestine—before they can develop into cancer. Rather than using a one-size-fits-all approach, this personalized treatment plan is designed to match each patient's individual risk and needs.
People with FAP have a very high lifetime risk of developing polyps in the stomach and duodenum, and some of these polyps can eventually turn into cancer. Currently, doctors use a standard scoring system to decide how often to monitor patients and when to remove polyps, but research shows this system doesn't always accurately predict which polyps will become dangerous. This trial aims to develop a better, more personalized approach that prevents cancer and avoids unnecessary surgery, which can have serious complications.
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As a participant, you would receive regular endoscopic examinations (using a camera to look inside your stomach and small intestine) based on your personalized surveillance plan. During these visits, doctors would identify polyps and remove any that show signs of concern using endoscopic techniques, rather than waiting for larger interventions or surgery. The study involves following this tailored monitoring and treatment protocol over time to prevent polyps from advancing to cancer while keeping you as healthy as possible.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Netherlands
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborators
Leiden University Medical Center, The Netherlands Cancer Institute
Enrollment target
~1,000 participants
Started
November 2020
Primary completion
November 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
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