Plain-English translation of NCT04681534 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing the AlphaDBS System, a new type of deep brain stimulation device designed for people with Parkinson's disease. Unlike standard devices that deliver steady stimulation all the time, the AlphaDBS System can adapt and adjust the stimulation based on your brain's activity in real time. The study will compare how well this adaptive approach works compared to the traditional fixed-stimulation approach.
Many Parkinson's disease patients already use deep brain stimulation, but the standard devices deliver the same level of stimulation constantly, which doesn't always match the patient's changing needs throughout the day. Researchers believe that a smarter, adaptive system could provide better symptom control with potentially fewer side effects.
The study has two phases. First, you'll spend 2 days in the hospital trying both types of stimulation — the new adaptive version and the standard fixed version — while doctors monitor your safety and symptoms. If you tolerate this well, you'll move to the second phase at home, where you'll use the AlphaDBS System in each mode for 2 weeks at a time over about 1 month total, with regular check-ins from your care team.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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