Plain-English translation of NCT04686682 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This is one of the first times this treatment has been tested in people.
This trial is testing a new medication called to see if it is safe and effective for treating advanced cancers, including lung cancer, blood cancers, ovarian cancer, and others. The medication works by blocking proteins in cancer cells that help them grow. Researchers want to find the right dose and understand how well the medication works against different types of advanced tumors.
Many patients with advanced cancers run out of standard treatment options or don't respond well to existing therapies. This medication represents a new approach to fighting cancer cells, and researchers need to test whether it's safe enough and effective enough to help patients in this situation.
You likely qualify if…
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The study has two parts: in Part 1, researchers will gradually increase your dose of the medication to find the safest and most effective level. In Part 2, more patients will receive the medication at the dose deemed safest from Part 1. You will have regular clinic visits to receive the medication, have blood tests, imaging scans, and other tests to monitor how well the treatment is working and check for any side effects.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
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