Plain-English translation of NCT04692337 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a device called an Ommaya Reservoir can help doctors better understand brain tumors by making it easier to collect cerebrospinal fluid (the fluid around your brain) multiple times over the course of your disease. Usually, collecting this fluid requires a lumbar puncture, which is uncomfortable and inconvenient. By placing the Ommaya Reservoir during your planned brain tumor surgery, future fluid samples can be collected quickly and easily through a simple needle tap under the scalp.
Brain tumors are difficult to treat, and progress in finding better therapies has been slow. Doctors believe that studying how cerebrospinal fluid changes over time could reveal important information about your tumor's behavior and whether treatments are working. However, collecting multiple fluid samples has been difficult because the standard method (lumbar puncture) is uncomfortable and inconvenient—so this device aims to make research participation easier and help speed up the discovery of better personalized treatments.
You likely qualify if…
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If you enroll, your surgeon will place the Ommaya Reservoir during your planned brain tumor surgery—it sits under your scalp with a thin tube reaching into the fluid space around your tumor. After surgery heals, you will return to the clinic at least 2 more times so doctors can use a small needle to collect fluid samples through the reservoir. Each collection is quick and much less uncomfortable than a traditional lumbar puncture. Your fluid samples will be stored and made available to researchers studying brain tumors, and the details of each sample collection will be carefully tracked.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Enrollment target
~100 participants
Started
January 2021
Primary completion
February 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Essa Sharif
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.