Plain-English translation of NCT04693377 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a combination approach to treat painful bone tumors in people with advanced cancer. Researchers want to see whether using cryoablation (a freezing technique that kills tumor cells) followed by stereotactic body radiation therapy (a focused, high-dose radiation treatment) works better than radiation therapy alone. The goal is to reduce pain and help patients need fewer pain medications.
When cancer spreads to the bones, it can cause severe pain that is hard to manage with medication alone. This trial exists because doctors want to find better ways to treat bone tumors and relieve pain so patients can live more comfortably with better quality of life.
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If you join, you will be randomly assigned to receive either radiation therapy alone, or freezing therapy followed by radiation therapy. Both treatments happen over a short period, and the freezing procedure (if assigned) happens first, with radiation within 10 days after. You will then come back for follow-up visits at 1, 2, 3, 4, 8, 12, 16, 20, and 24 weeks so doctors can check your pain, how well the treatment worked, and any side effects.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States