Plain-English translation of NCT04700527 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether (SCFA) supplements can help reduce gastrointestinal side effects in patients undergoing radiation therapy for abdominal or pelvic cancers. More than half of people who receive this type of radiation experience digestive problems, and this medication may help protect the healthy tissue in the gut from damage. Participants will take either the SCFA supplement or a placebo (a dummy pill) daily for about 2 weeks — starting one week before radiation begins and continuing for one week after it ends.
While radiation therapy is an effective cancer treatment, it often damages healthy tissue in the digestive tract, causing painful and disruptive side effects. This medication may offer a simple, natural way to protect the gut and help patients tolerate their cancer treatment better.
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You will be randomly assigned to receive either the SCFA supplement or a placebo, both taken as a powder mixed with food once daily. You'll start taking your assigned supplement one week before your radiation therapy begins and continue for one week after it ends. During this time, you'll keep a daily log of whether you took the medication, and you'll complete brief surveys about any side effects you experience. Your doctor will also track your symptoms at baseline, during treatment, and at follow-up visits for up to 5 years after your radiation is complete.
AI-generated summary from trial data · Sep 11, 2026 · Not medical advice
United States
Phase
Safety & dosing / Early efficacy
Sponsor
UNC Lineberger Comprehensive Cancer Center
Enrollment target
~122 participants
Started
December 2023
Primary completion
April 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Flora Danquah
UNC
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