Plain-English translation of NCT04720456 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a specialized ultrasound technique called SHAPE (Subharmonic Aided Pressure Estimation) can safely and accurately detect portal hypertension in children with liver disease. The study uses contrast agents — tiny bubbles injected into the bloodstream — to help the ultrasound create better images of blood pressure in the liver. Researchers want to see if this noninvasive method can catch the condition early, before serious complications develop.
Right now, doctors don't have a good noninvasive way to check if children with liver disease are developing portal hypertension until serious symptoms appear — sometimes too late. This medication could help detect the problem earlier, potentially preventing life-threatening bleeding and other dangerous complications.
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You will come in for one visit lasting about 4 to 8 minutes. A small IV line will be placed in your arm, and the study team will slowly infuse the contrast medication (tiny bubbles) mixed with saline while an ultrasound probe takes pictures of your liver. There is a 2-minute setup period, followed by 2 to 6 minutes of actual ultrasound imaging. The whole process is noninvasive and similar to a regular ultrasound, just with the added contrast to help doctors see blood pressure in your liver vessels more clearly.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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