Plain-English translation of NCT04723862 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing , a medication that blocks male hormone effects, to see if it can normalize hormone pulse patterns in teenage girls who have higher-than-normal levels of male hormones. Researchers will measure how the medication affects a specific hormone called LH, which plays a key role in reproductive health. The study compares the medication to placebo (a dummy pill) to see what difference, if any, the treatment makes.
Many teenage girls develop excess male hormones, which can lead to conditions like polycystic ovary syndrome (PCOS) later in life. Doctors want to understand exactly how this medication works in the teenage body and whether it can help normalize hormone patterns during puberty, potentially preventing or managing these long-term conditions.
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You would visit the research unit twice, at least 4 weeks apart. At each visit, you would take either the medication or placebo for 2 weeks beforehand, then stay overnight at the research unit where doctors would draw blood every 10 minutes through a small tube in your arm from early evening to early morning. They would also monitor your sleep during the night. One visit tests the real medication; the other tests placebo — but neither you nor the doctors will know which is which until the study ends.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States