Plain-English translation of NCT04731272 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Cystic Fibrosis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called dulaglutide to see if it can help improve insulin production in people with cystic fibrosis who have trouble controlling their blood sugar. Cystic fibrosis often damages the pancreas over time, making it harder for the body to manage glucose levels. This study wants to know if the medication can help preserve the pancreas's ability to produce insulin and slow or prevent diabetes from developing.
Diabetes is a serious complication that happens in many people with cystic fibrosis and leads to worse health outcomes. There aren't many good treatment options right now that specifically target the underlying insulin problems in cystic fibrosis, so researchers want to test whether this medication might help protect pancreatic function before diabetes fully develops.
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You will be randomly assigned to either receive the medication or be in an observation group with no treatment for 6 weeks. Both groups will have a special test at the start and after 6 weeks where you drink a meal-like beverage and have your blood sugar and insulin levels checked multiple times to see how your body is responding. If you're in the medication group, you'll give yourself a weekly injection under your skin for those 6 weeks.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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