Plain-English translation of NCT04731831 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Arthritis, Rheumatoid research guide →This trial is investigating why some people with arthritis don't respond as well to anti-inflammatory medications like infliximab or adalimumab. Researchers want to understand whether differences in how bodies handle the medication—related to gender, smoking, or weight—might explain why some patients benefit less. The study will follow 120 patients for a year, collecting blood samples to measure inflammation, antibodies, and medication levels.
These medications have helped many arthritis patients, but some groups—including women, smokers, and people with obesity—tend to have less success. Doctors don't yet understand why. This trial aims to find biological clues that could eventually help doctors predict who will benefit most and personalize treatment plans.
You likely qualify if…
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You would start taking your prescribed medication (infliximab or adalimumab) as part of your normal arthritis care. Over 12 months, you'd attend visits at baseline, 2 months, 4 months, and 12 months (or when treatment ends), where blood samples would be collected to measure inflammation markers, antibodies, and medication levels. Your health information would also be recorded in a standard Danish registry. The study integrates with your regular treatment, so there are no additional medications or procedures beyond blood draws.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Denmark
Sponsor
Aalborg University Hospital
Enrollment target
~120 participants
Started
August 2020
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Karen B Lauridsen, MD
Department of Clinical Medicine, Aalborg University and Aalborg University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.