Plain-English translation of NCT04740541 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research is testing whether men with Crohn's disease need more of an amino acid called threonine than current dietary guidelines recommend. Threonine is a building block your body gets from protein-rich foods. The study uses a special technique to measure how your body uses threonine by tracking markers in your breath after you eat different amounts of it.
Current nutrition guidelines for amino acids were created for healthy people, not for those with inflammatory bowel conditions like Crohn's disease. Animal studies suggest that people with Crohn's may actually need more threonine to support healing and reduce inflammation, but this has never been properly studied in humans. Better understanding of these nutritional needs could help doctors create personalized meal plans that help patients recover faster and stay in remission longer.
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You will visit the research center up to 5 times for study visits. At each visit, you'll eat a controlled diet with different amounts of threonine, and researchers will measure how your body processes it by collecting breath samples (which are tested for a harmless marker). The visits are spaced out so researchers can see how your body responds to each level. The whole process takes several weeks, and you'll need to follow the provided diet carefully during that time.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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