Plain-English translation of NCT04740580 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Alzheimer Disease research guide โPhase 1 โ Testing in a small group (usually 20โ80 people) to find a safe dose and watch for side effects.
This trial is testing whether a combination of two amino acids called glycine and N-acetylcysteine (NAC) can help slow cognitive decline and reduce brain inflammation in people with Alzheimer's disease. These amino acids are the building blocks your body uses to make glutathione, a natural protective substance in your brain that appears to be low in Alzheimer's patients. The medication aims to restore glutathione levels and reduce the oxidative stress and inflammation thought to damage brain cells.
Research suggests that low levels of glutathione in the brain contribute to brain damage, inflammation, and cognitive decline in Alzheimer's disease. This trial is testing whether replenishing glutathione with this medication might slow these processes and help preserve memory and thinking skills.
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You will take either the amino acid supplement or a placebo pill daily for 24 weeks. You will have brain imaging scans (MRI and PET scans) at the beginning and end of the study to measure changes in brain inflammation and glucose use. You will also complete memory and thinking tests at the start, at 12 weeks, and at 24 weeks to track any changes in your cognition during the study.
AI-generated summary from trial data ยท Jun 4, 2026 ยท Not medical advice
United States